Sunday, August 4, 2013

Fundamentally new antibiotics confusing dangerous bacteria

American researchers have prevented an antibiotic bacteria detects a human body, was developed. "Deceived" Microbes produce toxins and transit through the intestines of humans, "believe" it. In the environment, according to the journal Science Scientists from Southwestern Medical Center, the University of Texas found that the bacteria E. coli, Salmonella and Francisella tularensis (tularemia agent) knows the human body with a specific receptor that responds to hormones such as adrenaline and noradrenaline. This activates virulence genes from bacteria and infection begins, especially start forming microbial toxins. Antibiotic called LED209 blocks this receptor without killing the bacteria, but also makes them dangerous to humans. Study leader Vanessa Sperandio (Vanessa Sperandio) and her colleagues tested the antibiotic LED209 in mice with salmonella, tularemia or intestinal infection caused infected E. coli. The treatment was effective. It was found that the animals treated with the drug before or after a few hours of exposure, and more pleasant to survive common in a placebo. Were reported in the same serious side effects. Scientists noted that the spectrum of the new drug is not restricted to the three tested bacteria. Receptor, which is on the antibiotic, at least 25 agents - in particular the causative agent of Legionnaires' disease. A particular advantage of the new drug, it probably does not lead to the development of resistance, because it destroys bacteria, experts say.

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