Satiety hormone helps epilepsy

Intranasal (intranasal) administration "saturated hormone" leptin helps epilepsy. This is the result achieved by scientists at the University of Washington, reported the Journal of Clinical Investigation. Investigator Kelvin Yamada (Kelvin Yamada) and his colleagues conducted their experiments on rats. The animals artificially induced focus (focus) epilepsy by intracerebral injection of a substance called 4AP. Coadministration of leptin in the brain reduces the frequency and duration of attacks, and intranasal administration of this hormone are shifted their start. At the same time, in the absence of leptin receptors, this effect was not observed, the researchers reported. Further experiments showed that the anticonvulsant effect of leptin with an effect on intracellular signaling pathways and PI3K JAK2 is connected, the researchers found. So to use to combat epilepsy diet, increased serum leptin, intranasal administration of the hormone, and drugs, which included the JAK2 signaling pathway, PI3K, the scientists. Epilepsy is not uncommon. According to WHO, the disease affects approximately 50 million people in the world.