Senescent cells have "spoiled" genetic characteristics and secrete proteins that. Damage to the environment Researchers at the Mayo Clinic have to accelerate the American genes, and reverse the aging process are, according to a study in the journal "Nature Cell Biology". P16 and p19 - in the process of aging experiments on mice, biologists have the function of two genes investigated to suppress the growth of tumors. As a result, they found that p16 accelerates aging of cells, while p19 stops the process. "Scientists have aging mice derived lacked genes p16 or p19 under investigation, but these mice were not suitable for research, as they all died of cancer before the time to grow old. By crossing with other breeds of mice, the aging five times faster than normal was due to a mutation in the gene BubR1, we could do this was to get around, "- says the lead author of the study Darren Baker. Due to the fact that other genes are involved in the aging process, researchers have clearly established that p16 causes aging of tissues, whereas p19 counteracts this. It was completely unexpected, as experiments with tissue cultures showed that p19 contributes to aging, said co-author Jan van Derse. In this study, the researchers also found that the "start" and the development of the aging process, at least partially influenced by the accumulation of senescent cells in tissues and organs. These senescent cells have "spoiled" genetic characteristics and secrete proteins that damage to the surrounding cells, which. Malfunction of organs
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