American scientists have cured hemophilia in mice

Doctors from the Albert Einstein College of Yeshiva University (Yeshiva University) found that. Development of haemophilia A by a defect of endothelial cells of the liver Grafting donor cells from a healthy animal, they could cure hemophilia in mice, according to the Journal of Clinical Investigation. Hemophilia - a genetic disease in which damage is caused severe and prolonged bleeding due to impaired blood clotting. The most common form of hemophilia - Hemophilia A - due to the lack or insufficiency of the so-called factor VIII (antigemofilicheskogo globulin) in blood plasma. Previously it was thought that factor VIII is produced by hepatocytes - cells that the majority of the liver, and for most of the functions. However led scientists Sanzhiva Gupta (Sanjeev Gupta) proposed that the production of Factor VIII responsible sinusoidal endothelial cells of the capillaries of the liver. To confirm their theory, they carried out experiments on animals. With the aid of a substance called monokrotalin destroys own endothelial cells in the liver of mice with hemophilia A. Then, in their core, the flow into the liver, endothelial cells obtained from healthy donor mice injected. "Three months after transplantation, the study of the liver of mice, we found that the transplanted cells take hold and increase their numbers. More importantly, mice with transplanted cells, the factor VIII in an amount sufficient to completely fix Hemophilia A began, "- said the study's author Antonia Follentsi (Antonia Follenzi). Hemophilia A is suffering one of the ten thousand men. The current management of hemophilia weak. Opening of the American scientists could lead to new therapies, the question of human studies is premature. Now, experts are looking krotalinu alternatives that is very toxic drug.