Fruit juices injured absorption of drugs

Canadian scientists have discovered a new mechanism of interaction with fruit juices what. The inadmissibility of their joint reception It is the malabsorption of some drugs under the influence of the components of the juices. Until now it was known only to the grapefruit juice effect on the metabolism of certain drugs. It lies in the fact that bergamottin contained in grapefruit, the activity of the enzyme CYP3A4 which breaks inhibits 50 existing drugs. Thus increasing the concentration of these drugs in plasma and slow dissipation. Scientists at the University of Western Ontario, studied the interaction of grapefruit juice with antihistamine fexofenadine, which is metabolized by CYP3A4. These three groups of healthy volunteers were invited, fexofenadine with grapefruit juice, naringin solution (substances that give grapefruit bitter taste), and clean water. It was found that, during the taking of the drug with juice absorbed only half of the amount that can be absorbed when taken with water. The scientists also found that this effect is due to the fact that naringin OATP1A2 protein inhibits the transport of drugs from the intestine into the blood. Similar properties have been found in orange and apple juice. To date, a violation of sucking the juices under the following medications: beta-blockers atenolol, celiprolol and talinolola; cytostatic cyclosporin and etoposide, antimicrobial and antifungal drugs ciprofloxacin, levofloxacin and itraconazole. Study leader Professor David Bailey (David G. Bailey) believes that this list is not complete, and recalled that the drugs should drink clean water.