Known protein eliminates pain eight times more effective than morphine

Scientists from the U.S. and Finland have discovered that a protein long known to human nerve cells suppresses pain eight times more potent than morphine. This protein enzyme was stable to fluorine acid phosphatase (FRAP), in the cells of the pain system. It is the function of the cells of the system changes in the way that the activation of painful reactions followed by their suppression. To examine individual cell types, researchers label rule to the content of specific proteins specific to particular cells. As such a marker for nerve cells (neurons) of the perception of pain (nociceptive system) in the last 50 years with the fluoride-resistant acid phosphatase. However, the gene encoding this enzyme has not been identified. Researchers at the University of North Carolina previously noted that the structure identical FRAP enzyme acid prostate phosphatase (PAP). Upon request, researchers at the University of Helsinki brought genetically engineered mice that lacked a known gene PAP. In these mice lacking not only the PAP and FRAP, which shows the complete identity of these proteins. Bred mice differed dramatically increased sensitivity to pain. The introduction of excess FRAP in their CSF significantly reduced pain responses. Through the power of the analgesic effect of this protein was similar to morphine, but unlike him not to trade 5-6 hours and about three days. The scientists also discovered the mechanism by which the action is implemented FRAP. It is known that. The application of painful stimuli in nociceptive neurons, a large amount of ATP (adenosine triphosphate), which triggers a cascade of painful reactions FRAP dissolves ATP two phosphoric acid, whose conversion to AMP (adenozinmonofosfornuyu acid), which, on the contrary, is the reaction is suppressed. The researchers are now working on similar FRAP important nutrient conservation to find work when they administered.